血清免疫固定电泳、蛋白电泳、免疫球蛋白及轻链定量对多发性骨髓瘤临床诊断价值探讨

Clinical value of immunofixation electrophoresis,Serum protein electrophoresis,quantitative analysis of in diagnosis of multiple myeloma

目的探讨血清蛋白电泳、总蛋白、免疫球蛋白及轻链、蛋白电泳、免疫固定电泳测定对多发性骨髓瘤(MM)的诊断价值。方法对89例多发性骨髓瘤患者的血清总蛋白、免疫球蛋白及轻链、蛋白电泳、免疫固定电泳和尿轻链κ、λ的检测结果进行统计分析。结果 89例MM患者38例患者血清总蛋白含量升高;55例免疫球蛋白及轻链定量显著升高;血清蛋白电泳56例检出M带,而免疫固定电泳中89例均为阳性结果。结论免疫固定电泳检是MM诊断的敏感方法 ,应作为MM的常规检测方法 。

Objective Value of diagnosticing multiple myeloma by means of detecting serum protein electrophoresis,total protein,Protein electrophoresis and light chain,immunofixation electrophoresis is researched.Methods 42 hospitalized patients which are diagnosticed multiple myeloma are detected aboat serum protein electrophoresis,total protein,Protein electrophoresis and light chain,immunofixation electrophoresis and urine light chain κ、λ,then the test result is statisted and analysised.Results In 89 patients,38 cases were tested the content of serum total protein elevated,55 cases were tested immunoglobulin and quantitative light chain significantly increased,56 cases for serum protein electrophoresis test are M,89 cases for Immunofixation electrophoresis test are positive.Conclusion Detecting immunofixation electrophoresis for diagnosticing multiple myeloma is a sensitive method,and it is used to diagnost Multiple myeloma.