PEG介质中2-[4-氨基-5-(2-苯并呋喃基)-4H-1,2,4-均三唑-3-巯基]-N-苯乙酰胺的合成

Synthesis of 2-[4-amino-5-(2-benzofuranyl)-4H-1,2,4-triazol-3-thiol]-N-phenylacetamide in the medium of PEG

3-(2-苯并呋喃基)-4-氨基-5-巯基-1,2,4-三唑与氯乙酰苯胺衍生物在PEG-400介质中发生取代反应,制得相应的1,2,4-三唑-3-巯基-苯乙酰胺,产物结构经IR、NMR及元素分析进行了表征.结果表明,该方法具有产率高、污染少、操作简单、环境友好等优点.

2-[4-Amino-5-（benzofuran-2-yl）-4H-1,2,4-triazol-3-ylthio]-N-phenylacetamide are synthesized by the reactions of 1,2,4-triazoles with 2-chloro-N-phenylacetamides in PEG-400.The structures of all these new compounds are fully established by IR,NMR,and elemental analysis.The method has a few advantages of good yields,less pollution,simple operation and environmental friendliness.