EphB-2受体及HER-2与EGFR在结直肠癌中的表达与意义

Expression and significance of EphB-2 receptor,HER-2 and EGFR in colorectal cancer

目的探讨EphB-2受体、HER-2、EGFR的表达与结直肠癌生物学行为的关系。方法采用免疫组化染色检测86例结直肠癌组织标本中EphB-2受体、HER-2、EGFR的表达水平,以结直肠腺瘤组织标本47例作为对照。结果在癌旁无瘤黏膜、结直肠腺瘤和结直肠癌3组中,EphB-2受体的表达阳性率分别为100%(86/86)、95.7%(45/47)和83.7%(72/86);HER-2表达阳性率分别为34.9%(30/86)、42.6%%(20/47)和74.4%(64/86);EGFR表达阳性率分别为39.5%(34/86)、46.8%(22/47)和65.1%(56/86),癌旁无瘤黏膜、结直肠腺瘤与结直肠癌阳性率比较差异具有统计学意义(P<0.05)。在结直肠癌中EphB-2受体的表达与结直肠癌的分化程度、浸润深度、淋巴结转移有关,而HER-2、EGFR的表达与结直肠癌的浸润深度、淋巴结转移有关。结论 EphB-2受体、HER-2、EGFR对结直肠癌生物学行为有明显影响,可作为临床判断结直肠癌的生物学行为及预后的重要参考指标。

Objective To study the correlation between the biological behavior of colorectal carcinoma and the expression of EphB-2 receptor,HER-2 and EGFR.Methods The expression levels of EphB-2 receptor,HER-2 and EGFR in 86 cases of colorectal carcinoma were examined by immunohistochemical staining.Other 47 cases of colorectal adenoma samples were taken as controls.Results Compared with the normal mucosa or adenoma,the positive rate of EphB-2 receptor expressed in colorectal carcinoma significantly reduced from 100%（86/86）or 95.7%（45/47）to 83.7%（72/86）,HER-2 expression significantly increased from 34.9%（30/86）or 42.6%（20/47）to 74.4%（64/86）,and EGFR expression significantly increased from 39.5%（34/86）or 46.8%（22/47）to 65.1%（56/86）.The positive rates of the normal mucosa and colorectal adenoma had statistically significant differences with colorectal cancer（P0.05）.In colorectal cancer,the expression of EphB-2 receptor was related to its invasion depth,histological grade and lymph node metastasis,while the expression of HER-2 and EGFR was related to the invasion depth and lymph node metastasis.Conclusion EphB-2 receptor,HER-2 and EGFR can obviously affect the biological behavior of colorectal cancer.They may be important indexes to predict the biological behavior and prognosis of colorectal carcinomas.