正交实验法优选双黄巴布剂的基质配方

Study on Optimization of Matrix Prescription of Shuanghuang Cataplasm

目的优选双黄巴布剂的最优基质配方,制备性能优良的巴布剂。方法用正交实验法,以初黏力和持黏力为量化指标,结合膏体的均匀性、柔软性、涂展性、膜残留量及对皮肤的追随性等感观综合评分指标,优选双黄巴布剂的基质配方。结果双黄巴布剂的最优基质配方为NP700:聚乙烯吡咯烷酮K90:羧甲基纤维素钠:交联聚维酮XL-10:聚乙烯醇:高岭土:甘油:甘羟铝:酒石酸=3.00:1.00:0.5:0.5:0.25:2.5:15:0.08:0.16.结论按照最优基质配方制得的双黄巴布剂,其初黏力、持黏力、均匀性、柔软性及对皮肤的追随性等都良好,且使用方便。

Objective To optimize the matrix prescription of shuanghuang cataplasm to prepare better cataplasm.Methods L9 （34） orthogonal test method was used and tacking strength,cohesive strength and appearances were used as evaluation indices.Results The optimal matrix prescription of shuanghang cataplasm is NP700：PVPK-90：CMC-Na：Polyplasdone XL-10：PVA：Kaolin：Glycerol：Dihydroxyalumi-mun aminoacetate：Tartaric acid=3.00：1.00：0.5：0.5：0.25：2.5：15：0.08：0.16.Conclusion With this optimal matrix prescription better quality cataplasm can be prepared.