丙型肝炎病毒与庚型肝炎病毒混合感染及其对干扰素治疗的反应

The coinfection of hepatitis C virus with hepatitis G virus and its reaction to interferon treatment

目的研究丙型肝炎患者中庚型肝炎病毒（ＨＧＶ）混合感染情况。方法采用套式聚合酶链反应（ＰＣＲ）方法检测血清样本中的ＨＧＶＲＮＡ。结果６０例丙型肝炎患者血清中的ＨＧＶＲＮＡ阳性率为２３３％，其中慢性丙型肝炎患者的ＨＧＶ阳性率高于急性丙型肝炎患者。本组病例中，ＨＧＶ感染仅见于有输血或血制品史的患者。结论血液传播是ＨＧＶ感染的主要途径。ＨＧＶ的感染有可能导致输血后丙型肝炎的潜伏期缩短。在α－干扰素治疗丙型肝炎的过程中，ＨＧＶ的混合感染既不影响ＡＬＴ水平的下降和复常过程。

HGV RNA was detected in 60 cases of hepatitis C patients and its positive rate was 23.3%, also the HGV infection was more frequent in chronic hepatitis C patients than in acute hepatitis C, and was only detected in hepatitis C patients who experienced transfusion of blood or blood products. These results indicated that transfusion was the main transmission route for HGV infection. HGV infection could shorten the incubation period of post-transfusion hepatitis C, but it would not worsen the status of the disease. The coinfection of HCV and HGV did not interfere the effect of interferon treatment on hepatitis C patients either in normalization of ALT or the elimination of HCV.