孕激素非基因作用的研究进展

Progress in Non-genomic Action of Progesterone

孕激素与孕激素核受体结合,通过结合靶基因上的激素应答元件,调节靶基因表达,孕激素的这种作用被称为基因作用。但许多实验已证明,孕激素可不依赖孕激素核受体的转录活性产生快速调节作用,这些作用被称为孕激素的非基因作用。对于孕激素的非基因作用可以通过孕激素核受体与孕激素膜受体实现。对于孕激素非基因作用的研究对动物和人的许多生理变化有新的理解,并为激素依赖性恶性肿瘤的发生和药物治疗研究开辟了新的前景。

Progesterone can modulate the transcription of genes through the binding to nuclearlocalized receptor. However, progesterone can also exert fast, nontranscriptional effects through the binding either to the classical nuclear receptor or the progesterone membrane receptor. The research in non-genomic action of progesterone makes it easier to understand many physical changes in animal and human body, and it also open a new way to explain and treat the bormone-depanded malignant tumor.