摘要
目的:分析由临床常用的8味中药组成的血管性痴呆治疗方剂的主药、辅药和相应的剂量。方法:以脑缺血小鼠模型为实验对象,采用正交t值法进行试验设计,观察不同的药物组合对模型小鼠脑组织中乙酰胆碱酯酶(AChE)活力的影响。结果:确定了药物的组成和剂量。结论:新的处方可通过改善AChE活性,从而改善血管性痴呆学习记忆能力,对血管性痴呆具有显著治疗意义。
Objective:Analysis of Chinese herbal medicines by the eight composed of vascular dementia treatment of the main prescription drugs,and the corresponding dose of adjuvant.Methods:To cerebral ischemia mouse model of experimental objects,t value method using orthogonal experiment design,the effects of different drug combinations on mice brain tissue acetyl cholinesterase (Ach-E) activity effects.Results:To determine the composition of the drug and dose.Conclusion:The new prescription can be by improving the Ach-E activity in order to improve learning and memory ability in vascular dementia,vascular dementia have a significant therapeutic significance.
出处
《中华中医药学刊》
CAS
2010年第5期1078-1080,共3页
Chinese Archives of Traditional Chinese Medicine
关键词
正交T值法
血管性痴呆
乙酰胆碱酯酶
单侧颈动脉结扎
筛方
orthogonal t value design
vascular dementia
AChE
permanent occlusion of unilateral common carotid artery
screening prescription