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圆盘受体2与肝纤维化 被引量:2

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摘要 肝纤维化是机体针对各种慢性肝损伤所引发的修复反应。它主要是由肝星状细胞(hepatic stellate cells,HSC)激活并转化为肌成纤维样细胞后分泌大量的细胞外基质(extracellular matrix,ECM),大量沉积的ECM又促进HSC不断活化,从而导致肝纤维化的不断进展。
出处 《中华消化外科杂志》 CAS CSCD 2010年第2期159-160,共2页 Chinese Journal of Digestive Surgery
基金 上海市教育委员会课题(06BZ027)
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参考文献18

  • 1Moreira RK.Hepatic stellate cells and liver fibrosis.Arch Pathol Lab Med,2007,131(11):1728-1734.
  • 2刘立新,张骞骞,郭晓红,赵嘉慧,韩德五.胰岛素样生长因子结合蛋白相关蛋白1在活化肝星状细胞中的表达及意义[J].中华消化外科杂志,2008,7(1):49-52. 被引量:14
  • 3Hui AY,Friedman SL.Molecular basis of hepatic fibrosis.Expert Rev Mol Med,2003,5(5):1-23.
  • 4Olaso E,Ikeda K,Eng FJ,et al.DDR2 receptor promotes MMP-2mediated proliferation and invasion by hepatic stellate cells.J Clin Invest,2001,108(9):1369-1378.
  • 5Leitinger B.Molecular analysis of collagen binding by the human discoidin domain receptors,DDR1 and DDR2.Identification of collagen binding sites in DDR2.J Biol Chem,2003,278(19):16761-16769.
  • 6Vogel W,Gish GD,Alves F,et al.The discoidin domain receptor tyrosine kinases are activated by collagen.Mol Cell,1997,1(1):13-23.
  • 7Faraci E,Eck M,Gerstmayer B,et al.An extracellular matrixspecific microarray allowed the identification of target genes downstream of discoidin domain receptors.Matrix Biol,2003,22(4):373-381.
  • 8Mao TK,Kimura Y,Kenny TP,et al.Elevated expression of tyrosine kinase DDR2 in primary biliary cirrhosis.Autoimmunity,2002,35(8):521-529.
  • 9Zhou X,Jamil A,Nash A,et al.Impaired proteolysis of collagen I inhibits proliferation of hepatic stellate cells:implications for regulation of liver fibrosis.J Biol Chem,2006,281(52):39757-39765.
  • 10Yang K,Kim JH,Kim HJ,et al.Tyrosine 740 phosphorylation of discoidin domain receptor 2 by Sre stimulates intramolecular autophosphorylation and Shc signaling complex formation.J Biol Chem,2005,280(47):39058-39066.

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