体重指数与男性骨质疏松关系的研究

Study on the Relationship Between Body Mass Index and Osteoporosis in Males

对2003年8月至2005年12月因骨和/或关节疼痛麻木在四川大学华西医院门诊及住院1 207例男性经X线检查判断无骨质增生482人,采用法国DMS公司生产的Challenger双能X线骨密度仪测定L2～4正位骨密度,记录其身高、体重(计算体重指数)、症状、并发症、运动、吸烟等基线状况;测定L2～4骨密度,明确是否骨质疏松;用t检验或2检验比较骨质疏松组和无骨质疏松组基线状况,用逻辑回归分析实验对象中各种可能影响骨质疏松的因素与骨质疏松的相关性。结果显示:骨质疏松和无骨质疏松两组比较:体重指数、运动情况和吸烟比例有显著差异;高血压和糖尿病患病比例、年龄无明显差异;根据多因素分析,体重指数和吸烟是骨质疏松的危险因素,运动是骨质疏松的保护因素。BMI每增加一个单位,男性发生骨质疏松的风险增加0.654倍(P=0.004)。因此,我们认为体重指数是男性骨质疏松的危险因素,可能与体脂分布不同有关。

There were 482 male patients with non-hyperostosis diagnosed by X-ray among 1207 males who visited West China Hospital because of pain and/or numbness in bone or/and in joints from August 2003 to December 2005;the base-line information in records included age,stature,body weight（calculated BMI）,symptoms,co-morbidities,exercise frequency,and smoking.The bone mineral density of lumbar spine was determined and used to judge osteoporosis or non-osteoporosis.Comparison was made on the basic information between osteoporosis group and non-osteoporosis group by t test or X2 test statistical analysis;the relationship of multiple factors with osteoporosis was analyzed by Logistic Regression.The results of comparison between osteoporosis group and non-osteoporosis group indicated： there were significant differences among BMI,exercise and smoking,but no significant differences were seen among age,complications of hypertension and diabetes mellitus.According to the results of multiple regression analysis,BMI and smoking are the risk factors of osteoporosis,yet exercise is the protection factors of osteoporosis;the risk of osteoporosis increases by 0.654 times in men with BMI scaling up by 1kg/m2（P=0.004）.Therefore,we conclude that BMI is a risk factor of osteoporosis in male,and it may be related to body fat distribution.