n-HA/PA66复合生物活性融合器在颈椎病前路减压融合术中的初步应用研究

Preliminary Application of the Fusion Cage of Biomimetic n-HA/PA66 Composites in Anterior Cervical Intervertebral Fusion

分析52例颈椎病行前路减压、n-HA/PA66复合生物活性融合器植骨、钛钉板系统内固定颈椎前路重建手术患者的临床资料,探讨自行研制的纳米羟基磷灰石/聚酰胺66(n-HA/PA66)复合生物活性融合器在颈椎病前路减压固定融合手术中的初步临床疗效。所有术后均获得6～25个月(平均13个月)的随访。患者术前症状均得到改善,JOA评分术前平均为10.4分,术后为15.7分。n-HA/PA66复合生物活性融合器于术后3～6个月骨性融合。颈椎生理曲度、椎间高度、颈椎稳定性均维持良好。无融合器下沉、塌陷、移位发生,无感染、内固定物松动、脱落、断裂等并发症。n-HA/PA66复合生物活性融合器能有效重建和维持颈椎体的结构和高度,可能是一种理想的颈椎植骨替代材料。

This study was aimed to evaluate the preliminary efficacy and the safety of the fusion cage made of biomimetic nano-hydroxyapatite and polyamide 66（n-HA/PA66） composites for the structural reconstruction and the restoration of height of vertebral body in the case of cervical spondylosis by anterior surgical procedures.52 patients with cervical spondylosis,received the therapy by discectomy with or without vertebrae resection and decompression,and the fusion cage of n-HA/PA66 vertebra implant with bone chip,and titanium plate system was fixed. All cases were followed up for 6 to 25 months.All the patients＇ preoperative symptoms subsided without any serious complication,and no patient complained of lasting soreness.No effusion or flare was found,and no recurrence happened in the follow-up.The preoperative JOA score was 10.4,and post-operative JOA score 15.7.The X-ray films of all cases demonstrated successful fusion with good curvature and height,and there was no sinking or collapse.The stability was satisfactory;the reconstructive height of vertebra was maintained.No complications such as infection and screw broken came into being.The fusion cage of the biomimetic n-HA/PA66 composites can effectively restore the height and structure of vertebra.It may have the potential for use as a satisfactory prosthestic vertebral body replacement.