血管内皮生长因子在口腔扁平苔藓及鳞癌组织中的表达

Expression of vascular endothelial growth factor in oral lichen planus and squamous cell carcinoma

目的探讨血管内皮生长因子在口腔扁平苔藓癌变及发病机制中的作用。方法采用免疫组化法,检测10例正常口腔黏膜、25例口腔扁平苔藓、11例口腔扁平苔藓伴不典型增生及14例口腔鳞癌,上皮组织中血管内皮生长因子的表达水平。结果血管内皮生长因子在24例口腔扁平苔藓标本中阳性表达2例,阴性表达22例,阳性表达率明显低于其它3组(P<0.05)。扁平苔藓伴不典型增生及口腔鳞癌中血管内皮生长因子的阳性表达率均高于正常黏膜(P<0.05)。结论血管内皮生长因子的表达异常可能在口腔扁平苔藓的发生发展及癌变的过程中起作用。

Objective To examine the expression of VEGF in oral lichen planus（OLP）and oral squamous cell carcinoma.Methods The expression of VEGF was observed in 10 cases of normal oral mucosa,25 cases of OLP,11 cases of OLP with dysplasia and 14 cases of oral squamous cell carcinoma（OSCC） by immunohistochemistry.Results The expression of VEGF in OLP was significantly lower than those in normal oral mucosa,OLP with dysplasia and OSCC（P〈0.05）.The expression of VEGF in OLP with dysplasia and OSCC was significantly higher than that in normal oral mucosa.Conclusion The abnormal expression of VEGF may play a role in the development and carcinogenesis of OLP.