超声评价冠心病患者血管内皮舒张功能

Evaluation of vascular endothelial diastolic function in patients with coronary heart diseases by ultrasound

目的通过超声检测肱动脉内径评价冠心病患者肱动脉血管内皮舒张功能变化。方法采用高分辨率超声检测稳定型心绞痛、不稳定型心绞痛、急性心肌梗死患者及正常对照组血流介导的肱动脉血管舒张功能和硝酸甘油介导的肱动脉血管舒张功能。结果冠心病各组血流介导的血管舒张反应均较正常对照组降低(P<0.05)。稳定型心绞痛组与正常对照组,硝酸甘油介导的血管舒张反应无显著性差异(P>0.05),而不稳定型心绞痛组和急性心肌梗死组硝酸甘油介导的血管舒张反应均低于正常对照组与稳定型心绞痛组(P<0.05)。结论冠心病患者存在内皮舒张功能损害,这种损害呈渐进性发展。

Objective To evaluate the vascular endothelial diastolic changes in patients with coronary heart diseases （CHD） by measuring braehial artery diameter with ultrasound. Methods Patients with stable angina pectoris , unstable angina pectoris, acute myocardial infarction and normal controls were enrolled in this study. Flow-mediate dilation （FMD） and Nitroglycerin-mediated dilation （NMD） in the brachial artery were evaluated by high resolution ultrasound. Results FMD was significantly decreased in all CHD groups than that in control group（ P 〈 0.05 ） , and there was no significant difference of NMD between stable angina pectoris group and control group （ P 〉 0.05 ） , while NMD in unstable angina pectoris group and acute myocardial infarction group was significantly lower than that in stable angina pectoris group and control group （ P 〈 0.05 ）. Conclusion Endothelial diastolic function is impaired in patients with CHD, and this damage is gradually aggravated.