摘要
谷氨酸受体可分为促离子型谷氨酸受体(iGluR)和促代谢型谷氨酸受体(mGluR),促离子型受体可分为NMDA型受体和非NMDA型受体。促代谢型受体包括mGluR1～mGluR88种。其在中枢神经系统分布广泛,与突触的可塑性、谷氨酸的兴奋毒性、神经元的损伤与保护、长时程增强(LTP)和长时程抑制(LTD)、学习和记忆等多种功能密切相关。在弱视方面研究较多的是NMDA受体,其数量、活性在弱视组与正常组相比都有显著性差异。
Glutamate receptor can be divided into metabotropic receptor（mGluR） and ionotropic receptor（iGluR）. The iGluR includes NMDA receptor and non-NMDA receptor. mGluR includes mGluR1 to mGluR8. They are mainly distributed in the central nervous system （CNS） . They have an important role in synaptic plasticity, exitotoxicity of glutamate, protection and damage of neuron, long-term potentiation（LTP） and long-term depression（LTD）, study and memory. The NMDA receptor is studied considerably in amblyopia. There are significant differences in quantity and activity between contrast group and amblyopia group.
出处
《国际眼科杂志》
CAS
2010年第5期915-917,共3页
International Eye Science
关键词
谷氨酸受体
突触可塑性
弱视
兴奋毒性
glutamate receptor
synaptic plasticity
amblyopia
exitotoxicity of glutamate
