苦碟子联合奥扎格雷钠治疗2型糖尿病下肢血管病变疗效观察

Effects of sowthistle-leaf ixeris seedling in combination with sodium ozagrel on type 2 diabetes patients with crura vascular diseases

目的:研究苦碟子联合奥扎格雷钠在治疗2型糖尿病下肢血管病变的临床疗效和对患者血液流变学的影响。方法:将110例2型糖尿病下肢血管病变患者随机分为两组,治疗组(n=55)予以常规措施并加苦碟子注射液联合奥扎格雷钠注射液治疗,对照组(n=55)以常规措施并加复方丹参注射液治疗。观察治疗前后临床表现、踝臂指数(ABI)和血液流变学的变化。结果:两组治疗后临床表现较治疗前有改善,但治疗组疗效较对照组更显著(P<0.05);两组治疗后ABI和血液流变学指标均有改善,与治疗前比较具有显著性,但治疗组的改善差异更具有显著性(P<0.05)。结论:苦碟子联合奥扎格雷钠可显著改善下肢血液循环的高凝、高黏状态,是治疗糖尿病下肢血管病变的有效途径。

Objective： To observe the effects of sowthistle-leaf ixeris seedling in combination with sodium ozagrel on type 2 diabetes patients with crura vascular diseases.Methods：110 cases of type 2 diabetes patients with cruravascular diseases were randomly divided into treatment group （n=55） who were given normal measures and sowthistle-leaf ixeris seedling in com bination with sodium ozagre,and control group（n=55） who were given common measures and compound danshen injection. Investigated the change of clinical manifestation,ABI and hemorheology before and after treatment. Results：Both groups were improved on ABI and hemorheology compared with before treatment （P〈0.05）, the treatment group were signfiantly better than those in the control group （P〈0.05）.Conclusion：Sowthistle-leaf ixeris seedling in combination with sodium ozagrel has better action on improving hemorheology. It is an effective method for treating diabetes patients with crura vascular diseases.