异常黏液质清除剂尿通卡克乃其片的药效学实验研究

The Pharmacological research on the Kursi Kaknaq of mushil of abnormal balham

目的:本文对尿通卡克乃其片(100%处方原药粉)的急性毒性、镇痛及抗感染作用进行了研究。方法:①小鼠最大耐受量法。②小鼠醋酸扭体法观察尿通卡克乃其片(0.26、0.51、1.02g/kg)的镇痛功效。③大鼠分别通过足跖肿胀实验和棉球肉芽肿实验观察尿通卡克乃其片(0.20、0.40、0.80g/kg)的抗感染功效。结果:①尿通卡克乃其片的小鼠最大耐受剂量(MTD)为9.22g生药/kg,为临床拟用剂量成人每天每公斤用量的144倍。②与模型组比较,小剂量组(0.26g/kg)、前列通瘀胶囊组(0.80g/kg)能明显降低小鼠扭体次数(P<0.01)。其余剂量组(0.51、1.02g/kg)亦能降低小鼠扭体次数,但其差异没有统计学意义(P>0.05)。③与模型组比较,中剂量组(0.40g/kg)、前列通瘀组(0.60g/kg)能明显降低大鼠棉球肉芽肿湿重(P<0.05,P<0.01)。其余剂量组(0.20、0.80g/kg)亦能降低肉芽肿湿重,但其差异无统计学意义(P>0.05)。④与模型组比较,不同剂量组(0.20、0.40、0.80g/kg)、前列通瘀胶囊组(0.60g/kg)均具有抑制大鼠足趾肿胀的作用(P<0.05、P<0.01)。结论:尿通卡克乃其片(100%处方原药粉)急性毒性很小,具有一定的镇痛、抗感染作用。

Objective： To investigate the acute toxicity of Kursi Kaknaq, and its anti-inflammatory and analgesia effects on animal model. Methods： A few conventional models were used, such as the mice＇s twisting body response induced by acetic acid. The edema of rat hind paws elicit by carrageenan kappa type and the granuloma induced by cotton pellet; then were observed the pharmacological effects of Kursi Kaknaq. Results： ①Kursi Kaknaq＇ maximum tolerance dose was 9.24 g crude drug/kg. ②Comparing with model group, Kursi Kaknaq （0.26 g/kg） can significant decrease the mice＇s twisting body response induced by acetic acid （P〈0.01）. ③Comparing with model group, Kursi Kaknaq （0.40 g/kg） can inhibit the granuloma （wet weight） induced by cotton pellet. ④Comparing with model group, Kursi Kaknaq（0.20, 0.40, 0.80 g/kg）can inhibit the swelling induced by carrageenan kappa type （P〈0.05, P〈0.01）. Conclusion： Kursi Kaknaq＇ acute toxicity is low, and possesses certain anti-inflammatory and analgesia effects.