儿童急性淋巴细胞白血病和急性粒细胞白血病发病初期微量元素及营养相关蛋白的变化

Changes of some trace elements and nutritional proteins in children with acute lymphoblastic leukemia and acute myeloid leukemia at stages of onset

目的 探讨儿童急性淋巴细胞白血病和急性粒细胞白血病发病初期某些微量元素及营养相关蛋白的变化。方法应用原子吸收光谱法、散射比浊法、干化学法和化学发光法等，对73例急性淋巴细胞白血病和I26例急性粒细胞白血病发病初期的患儿血清铜、锌、铁、镁、磷、钙、铜蓝蛋白、铁蛋白、转铁蛋白、乳酸脱氧酶、总蛋白、白蛋白、血红蛋自含量和红细胞数量等指标进行检测，并与30名正常儿童相比较，运用t检验分析两个发病组和正常对照组之间这些指标的变化。结果发病组与对照组相比，除锌和磷含量的差异无统计学意义外，其余指标的差异均有统计学意义（P〈0．05），发病组的铜、镁、铁、铁蛋白、铜蓝蛋白和乳酸脱氯酶含量显著高于对照组（P〈0．05），而钙、转铁蛋白、总蛋白、白蛋门、血红蛋门含晕和红细胞数量显著低于对照组（P〈0．05）。急性淋巴细胞白血病与急性粒细胞白血病相比，在铁及铜锌代谢的相关指标方面的差异有统计学意义（P〈0．05）。结论儿童急性淋巴细胞白血病和急性粒细胞白血病发病初期，血清中一些微量元素与营养相关蛋白含量与正常状态相比，发生紊乱，失去平衡。

Objective To investigate the changes of serum trace elements and nutritional proteins in children with acute lymphohlastie leukemia and acute myeloid leukemia at the stage of onset. Methods Serum levels of cuprum, zinc, iron, magnesium, phosphorus, calcium, ceruloplasmin, ferritin, transferrin, lactate dehydrogenase, total protein, albmnin, hemoglobin, and erythrocytes were detected in 73 patients with acute lymphobtastic leukemia, 26 patients with acute myeloid leukemia at stages of onset, and 30 healthy controls using methods including atomic absorption spectrometry, nophelometry assay, dry chemical method, and/or chemiluminescence method. The differences of these indicators among these three groups were analyzed by t test. Results Serum levels of all detected elements except for zinc and phosphorus were significantly different between the onset groups and the control group （P 〈 0.05）. Serum levels of cuprum, magnesium, iron, ferritin, eeruloplasmin, and lactate dehydrogenase in the onset groups were significantly higher than those in control group （ all P 〈 0. 05 ）. On the contrary, calcium, transferrin, total protein, albumin, hemoglobin, and erythrocyte count were significantly lower in the onset groups than those in control group （P 〈 0. 05 ）. Serum iron, cuprum, zinc, and their metabolism were significantly different between acute lymphoblastic leukemia group and acute myeloid leukemia group （ P 〈 0. 05 ）.Conclusion Serum levels of some trace elements and nutritional proteins are disordered and out of balance in children with acute lymphoblastic leukemia and acute myeloid lenkemia at stages of onset.