栀子苷对急性乙醇中毒致小鼠学习记忆障碍的改善作用

The Protective Effects of Geniposide on Memory Impaired Mices Induced by Acute Alcoholic Intoxication

目的:研究栀子苷(geniposide)对急性乙醇中毒小鼠空间学习和记忆障碍的改善作用。方法:采用一次灌胃乙醇(50%,7mL.kg-1)造成小鼠空间学习记忆障碍,应用Morris水迷宫实验观察栀子苷(10,20,40mg.kg-1,ig,10d)对乙醇致空间学习记忆障碍模型小鼠的保护作用。结果:栀子苷各剂量组均能改善急性乙醇中毒所致的小鼠空间学习和记忆障碍,能明显缩短寻找站台潜伏期和游泳路径。结论:栀子苷可预防急性乙醇中毒所致的空间学习和记忆障碍。

Objective：To study the protective effects of geniposide on dysfunction of learning and memory in mice induced by ethanol.Methods：In order to induce learning and memory impairments for mices,ethanol（50%,7mL·kg^-1）was administrated by single injection into the stomach of mice respectively.The protective effects of geniposide（10,20,40mg·kg^-1,ig,10d）on the dysfunction of memory were observed by Morris water maze experiment.Relusts：Geniposide（10,20,40mg·kg^-1）can improve the learning and memory impairment induced by ethanol（50%,7mL·kg^-1）in mice,and significantly decurtate the escaping latency and swimming distance.Conclustion：Geniposide had a preventive effect on dysfunction of learning and memory in mice induced by ethanol.