1621例药品不良反应报告分析

Analysis of 1621 ADR cases reports

目的:了解常德市药品不良反应(ADR)发生的特点及规律。方法:对常德市药品不良反应监测中心2008年1月～2009年12月收集到的1621例ADR报告分别从患者年龄、给药途径、品种类别、ADR临床表现等方面进行回顾性分析与评价。结果:1621例ADR报告中涉及药品7类共95个品种,其中以抗感染药引起的ADR发生率最高,为883例(54.5%);中药注射剂345例(21.3%);静脉滴注987例(60.9%);皮肤及其附件损害占33.1%。结论:必须重视药品不良反应监测工作,加强药师与临床的沟通交流,减少或避免ADR的发生。

Objective：To investigate the characteristics and reqularity of adverse drug reaction（ADR）.Methods：1 621 ADR cases reports were collected from January 2008 to December 2009.Analyzed retrospectively in respect of age of patients,route of administration,drug kinds,systems and organs of ADR involved.Results：A total of 95 kinds of drugs belong to 7 major categories of drugs were involved in 1 621 ADR cases reports,antiinfective drugs dominated the first place,883 cases（54.5%）were associated with antiinfective,and 345 cases（21.3%）were induced by intravenous administration.33.1% were reported on the skin and local lesion（33.1%）.Conclusion：It is important to intensify ADR monitoring,facilitating communication between pharmacists and clinician in order to reduce or avoid ADR events.