摘要
目的探讨湖南怀化汉族人亚甲基四氢叶酸还原酶(MTHFR)基因的分布特征,并与其它地区人群进行比较。方法采用限制性内切酶片段长度多态(RFLP)技术检测120例健康个体的MTHFR基因的分布情况,并结合文献进行了与其它地区与民族的MTHRF分析比较。结果怀化汉族人MTHFR基因中有三种基因型T/T、T/C和C/C,其频率分别是12.5%、34.2%和53.3%。MTHFR基因T频率是0.296,基因C频率是0.704。结论怀化汉族人与其它地区人种MTHFR基因的分布规律有差异。
Objective： To investigate the distribution feature of MTHFR C677T genes in Han population in Huaihua. Mehtords： RFLP was used for genetyping of MTHFR C677T in 120 healthy subjects. Results ： There were three kinds of genetypes ： homozygousmutation Tr - type, heterozygousmutation CT - type, and wild - type CC, and their frequencies were 12. 5%, 34. 2% and 53. 3%, respectively. Conclution： There is a significant difference among different races and regions in gene polymorphisms distribution of the MTHFR C677T.
出处
《中国优生与遗传杂志》
2010年第5期18-19,共2页
Chinese Journal of Birth Health & Heredity
关键词
亚甲基四氢叶酸还原酶基因
怀化汉族人
多态性
Methylenetetraphydrofolate ruductase
The Hans population in Huaihua
Polymorphism
