白血病抑制因子及其受体在早产胎盘组织及蜕膜组织中的表达及临床意义

Expression and the clinical significance of the leukemia inhibitory factor and its receptor in preterm placental tissue and decidua tissues

目的探讨早产胎盘及蜕膜组织中的白血病抑制因子(LIF)及其受体(LIFR)的表达。方法应用免疫组织化学方法检测白血病抑制因子(LIF)及其受体(LIFR)在30例早产(实验组)、30例人工流产(对照组)胎盘和蜕膜组织中的表达。用卡方检验(Chi-Square Test)检测LIF、LIFR在早产和人工流产中的表达是否有差异。结果 LIF、LI-FR在早产胎盘组织中阳性率分别为6.7%和10%,在蜕膜组织中阳性表达率分别为10%和13.3%,结论白血病抑制因子(LIF)及其受体(LIFR)对晚期妊娠的维持有待进一步研究。

Objective： To study the expression of the leukemia inhibitory factor （LIF） and its receptor （LIFR） in preterm placental tissue and decidua tissues. Methods： Immunohistochemical staining to detect leukemia inhibitory factor （LIF） and its receptor （LIFR） in 30 cases of preterm birth （experimental group）, 30 cases of artificial abortion （control group） placenta and decidua tissue. Using chi -square test （Chi -Square Test） test LIF, LIFR in preterm and artificial abortion of the expression whether there are differences. Results： The LIF, LIFR in preterm placental tissues positive rates were 6. 7% and 10% and in decidual tissues positive rates were 10% and 13.3%. Conclusion： The leukemia inhibitory factor （LIF） and its receptor （LIFR） for the maintenance of late pregnancy remains to be studied further.