妊娠并发溶血、肝酶升高、血小板减少综合征22例临床分析

Clinical analysis of 22 cases on hemolysis,elevated liver enzymes,and low platelet count(HELLP)syndrome

目的探讨妊娠期高血压疾病并发溶血、肝酶升高、血小板减少综合征(HELLP综合征)对母儿预后的影响。方法对我院近7年来发生的22例HELLP综合征患者的临床资料进行回顾性分析。结果完全性HELLP综合征8例,部分性HELLP综合征14例:孕产妇死亡1例,围产儿23例,死亡10例,死亡率分别为4.5%及43.5%;且血小板计数和乳酸脱氢酶(LDH)水平与该病的严重程度相关。结论 HELLP综合征一旦确诊,特别是血小板和LDH异常,应尽快终止妊娠。同时重视对基础病的诊治和加强围产期保健,以降低母儿死亡率。

Objective： To eveluate the prognosis of materal, neonatal with severe preeclampsia, eclampsia, Hemolysis, Elevated Liver enzymes, and Low Platelet count（HELLP） syndrome. Methods ：22 cases of HELLP syndrome were collected retrospectively analysed in our hospital in the last 7 years. Results ：8 pations were diagnosised completely HELLP syndrom and 1 pation was dead. lg pations wete diagnosised patialy HELLP syndrom. There were 23 perinatal infants including 1 twins and 11 of them were dead. The perinatal mortality was 5.6% and the neonatal mortality was 47.4%. Besides. there was closedly relationship between Platelet count and Lactic Dehydrogenase（LDH） to the degree of the illnese. Concludsion： Once HELLP syndron been accurately diagnosised, especilally annormal Platelets count and elevated LDH, the pregnance would be terminated as early as possible. Stabilize the general condition of the mother will prevent the development of serious complications and reduce the perinatal and neonatal mortality.