期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

二甲双胍对多囊卵巢综合征患者胰岛素抵抗及排卵的影响 被引量：7

原文传递
导出
摘要 目的探讨胰岛素增敏剂二甲双胍对多囊卵巢综合征(PCOS)的胰岛素抵抗及排卵的治疗效果。方法把60例月经稀发或闭经的PCOS患者,随机分成三组,20例给予克罗米酚治疗(克罗米酚组),20例给予二甲双胍治疗(二甲双胍组),20例给予二甲双胍及克罗米酚联合治疗,在用药8周后比较各组治疗前后体重指数、腰臀比、黄体生成素(LH)、黄体生成素(LH)与卵泡刺激素(FSH)比值、睾酮及血清胰岛素水平与排卵率的变化。结果经用二甲双呱治疗8周后,测定血LH、LH/FSH、睾酮、血清胰岛素水平有明显下降,差异有显著性(P<0.01)。二甲双胍组中有8例诱发排卵,克罗米酚组有12例诱发排卵,联合治疗组有18例诱发排卵。结论二甲双胍能改善并诱发排卵功能,并增强多囊卵巢综合征患者对克罗米酚的敏感性。
作者 胡玉君 孙靖
机构地区 牡丹江市妇女儿童医院生殖科 牡丹江市妇幼保健院
出处 《中国优生与遗传杂志》 2010年第5期77-77,109,共2页 Chinese Journal of Birth Health & Heredity
关键词 多囊卵巢综合征 胰岛素抵抗 二甲双胍
分类号 R711.75 [医药卫生—妇产科学]
  • 相关文献

参考文献6

  • 1李国华,黄薇.二甲双胍在多囊卵巢综合征的应用[J].实用妇产科杂志,2005,21(9):534-537. 被引量：34
  • 2Macial GA, Soares JM, Alves El, et al. Nonobese women with polycystic ovary syndrome respond better than obese women to treatment with meffonnin[ J]. Fertil Steril,2004,81 (2) :355 -360.
  • 3Yarali H, Yildiz BO, Demirol A, et al. Co administration of metformin during rFSH treatment in patients with clomiphene citrate resistant polycystic ovarian syndrome :a prospective randomized trial[ J ]. Hum Reprod,2002,17 (2) :289-294.
  • 4陶建英,徐惠民.二甲双胍治疗多囊卵巢综合征胰岛素抵抗的临床观察[J].苏州大学学报（医学版）,2003,23(2):200-201. 被引量：41
  • 5Muberra K, Eray C, Coskun S, et al. Mefformin therapy improves ovulatory rates, cervical scores, and pregnancy rates in clomiphene cit- rate2resistant women with polycystic ovary syndrome [ J ]. Fertil Steril, 2002,77(1) :101-106.
  • 6George SS, George K, Irwin C, et al. Sequential treatment of metformin and clomiphene citrate in clomiphene2resistant women withpolycystic ovary syn2 drome : a randomized, controlled trial [ J ]. Hum Reprod, 2003,18(2) :299-304.

二级参考文献17

  • 1Wu XK,Zhou SY,Sallinen,et al.Ovarian selective resistance to insulin signaling in the polycystic ovary syndrome.Fertil Steril,2003,80(4):954～965.
  • 2Karen ER,Evelyn OT,Jeanne VZ,et al.Evidence for competing effects of body mass,hyperinsulinemia,insulin resistance,and androgen on leptin levels among lean,overweight and obese women with polycystic syndrome.Fertil Steril,2002,78(3):479～486.
  • 3Macial GA,Soares JM,Alves El,et al.Nonobese women with polycystic ovary syndrome respond better than obese women to treatment with metformin.Fertil Steril,2004,81(2):355～360.
  • 4Glueck CJ,Goldenberg N,Pranikoff J,et al.Height,weight,and motor-social development during the first 18 months of lifes in 126 infants born to 109 mothers with polycystic ovary syndrome who conceived on and continued metformin through pregnancy.Hum Reprod,2004,19(6):1323～1330.
  • 5Genazzani AD,Battaglia C,Malavasi B,et al.Metformin administration medolates and restore luteining hormone spontaneous episodic secretion and ovarian function in nonobese patients with polycystic ovary syndrome.Fetil Steril,2004,81(1):114～119.
  • 6Gleuck CJ,Wang P,Fontaine R,et al.Metformin to Restore Normal Menses in Oligo-Amenorrheic Teenage Girls With Polycystic Ovary Syndrome (PCOS).J Adol Health,2001,29(3):160～169.
  • 7Kolodziejczyk B,Duleba AJ,Spaczynski RZ,et al.Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome.Fertil Steril,2000,73(6):1149～1154.
  • 8Laure C,Morin-Papunen,Ilkka V,et al.Endocrine and metabolic effect of metformin versus ethinyl estradiol-cyproterone acetate in obese women with polycystic ovary syndrome:a randomized study.J.Clin.Endocrinol.Metab,2000,85(9):3161～3168.
  • 9Morin-Papunen L,Vauhkonen I,Koivunen R,et al.Metformin versus ethinyl estradiol-cyproterone acetate in the treatment of nonobese women with polycystic ovary syndrome:a randomized study.J Clin.Endocrinol.Metab,2003,88(1):148～156.
  • 10Elter K,Imir G,Durmusoglu F.Clinical,endocrine and metabolic effects of metformin added to ethinyl estradiol-cyproterone acetate in non-obese women with polycystic ovarian syndrome:a randomized controlled study.Hum Reprod,2002,17(7):1729～1737.

共引文献72

同被引文献30

引证文献7

二级引证文献58

中国优生与遗传杂志
2010年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部