生殖道支原体感染与男性不育关系的探讨及药敏结果的分析

Discussion of association between mycoplasma infection and male infertility and the drug resistance of mycoplasma

目的探讨生殖道支原体感染对男性不育的影响及其耐药情况。方法采用培养的方法对我院生殖中心就诊的不育男性患者生殖道分泌物进行检测,同时进行精液常规检查。结果不育组的支原体感染率与对照组比较有显著差异(P<0.05),主要影响精液常规中a+b级精子的活率(P<0.05),对喹诺酮类药物氧氟沙星(OFL)、左氧氟沙星(LEV)和司帕沙星(SPA)的耐药率呈较高水平,大环内酯类药物阿奇霉素(AZI)和罗红霉素(ROX)耐药率较高。结论男性不育与生殖道支原体感染有密切的关系,强力霉素(DOX)、美满霉素(MIN)和交沙霉素(JOS)为治疗支原体的首选药物。

Objective： To investigate the assoeiation of Mycoplasma infection in infertile men, discuss the drug resistance of mycoplasma. Methods ： Myeoplasma were detected respectively in the infertile men in the Reproduetive Medicine Centre of our hospital, at the same time, sperm detection were done. Results： The infection rates of Uu and Mh in infertile group were signifieantly higher than those in the eontrol （ P 〈0.05） ; and drug resistance to commonly used antibiotics of Du-6859a （OFL, LEV and SPA） was high, MIs antibioties （ AZI, ROX ） had a high drug - resistane rate, the drug - resistance rates of quinolones and MIs antibioties were high persistently. Conclusion： There was closely correlation between mycoplasma infection in female infertility, and deoxyeyeline, minocyeline and josamycin were the first choice drug to cure myeoplasma.