吸烟导致的氧化应激在慢性阻塞性肺疾病发病机制中的作用

Effect of cigarette smoke extract induces oxidative stress in the pathogenesis of chronic obstructive pulmonary disease

慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）是一种可以预防、可以治疗的疾病，以不完全可逆的气流受限为特征；气流受限呈进行性加重，与肺部对有害气体或颗粒的异常炎症反应有关。COPD的发病机制有多种，其中吸烟是影响COPD的一个主要的危险因素。吸烟引起氧化应激可直接损伤气道上皮，加重气道的炎症反应、炎前基因的表达，并导致蛋白酶／抗蛋白酶失衡最终导致气流受限。

Chronic obstructive pulmonary disease （COPD） is a disease which can be prevented and cured. COPD is characterized by the progressive development of airflow limitation that is not fully reversible and associated with an abnormal inflammatory response of the lungs to noxious particles or gases,particularly cigarette smoke. Smoking cigarettes is the major risk factor for COPD. Cigarette smoke can aggravate airspace epithelial injury, inflammatory response, pro inflammatory gene transcription and protease/anti protease imbalance in the lungs which leads to airflow limitation finally.