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Th17细胞和Treg细胞的细胞因子调节网络 被引量：30

Regulatory role of cytokines to Th17 cells and Treg cells in immune system
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摘要 Th17细胞和Treg细胞是CD4+T细胞的新亚群,在分化发育、功能发挥的过程中受到Th1型、Th2型效应细胞以及自身分泌产生细胞因子的调节,参与自身免疫病、感染、肿瘤等疾病的发生发展。通过对Th17和Treg分化发育、和功能发挥过程中的关键调节因子进行阻断或加强,可以上调或下调Th17和Treg在疾病中的表达,以用于疾病的预防和诊治。 Th17 cells and Treg cells,two new subtypes of CD4^＋ T cells,were regulated by cytokines secreted by a variety of immune cells during the differentiation and development processes,taking an important part in autoimmune disease,tumor immune evasion,transplant rejection and so on.These may be newly methods and paths on preventing and curing diseases by up or down regulation the expression of Th17 cells and Treg cells in immune responses through blocking or enhancing key regulatory cytokines of Th17 cells and Treg cells.
作者 王维维 沈茜
机构地区 第二军医大学长海医院实验诊断科
出处 《生命的化学》 CAS CSCD 北大核心 2010年第2期269-273,共5页 Chemistry of Life
关键词 TH17细胞 TREG细胞 细胞因子 Th17 cell Treg cell cytokine
分类号 R392 [医药卫生—免疫学]
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参考文献30

  • 1Sallusto F et al. Heterogeneity of CD4^+ memory T cells: functional modules for tailored immunity. Eur J Immunol, 2009, 39:2076-2082.
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二级参考文献9

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共引文献13

同被引文献430

引证文献30

二级引证文献166

生命的化学
2010年 第2期

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