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p53上调凋亡调制物的促凋亡作用 被引量：6

Promoting apoptotic effect of p53 up-regulated modulator of apoptosis
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摘要 p53上调凋亡调制物(p53up-regulated modulator of apoptosis,PUMA)是Bcl-2家族中BH3-only(Bcl-2 homology 3-only)蛋白质家族成员,通过其BH3结构域与所有的Bcl-2抗凋亡蛋白质结合,引发线粒体功能障碍和胱天蛋白酶(caspase)级联反应,诱导细胞凋亡。PUMA被证实在多种病理性应激介导的细胞凋亡中发挥着至关重要的作用,因而成为近年研究的热点。 p53 up-regulated modulator of apoptosis （PUMA） is a Bcl-2 homology 3 （BH3）-only Bcl-2 family member.It triggers apoptosis through its BH3 domain,which can bind and antagonize all known anti-apoptotic Bcl-2 family proteins to induce mitochondria dysfunction and activate caspase cascade.PUMA has become the research hotspot in recent years because it was confirmed to play a key role in apoptosis induced by many types of pathological stress.
作者 付晶晶 万福生
机构地区 南昌大学基础医学院生物化学与分子生物学教研室
出处 《生命的化学》 CAS CSCD 北大核心 2010年第2期286-290,共5页 Chemistry of Life
关键词 p53上调凋亡调制物(PUMA) 凋亡 P53 BH3-only蛋白质 p53 up-regulated modulator of apoptosis （PUMA） apoptosis p53 BH3-only protein
分类号 R362 [医药卫生—病理学]
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参考文献31

  • 1Yu Jet al. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell, 2001, 7:673-682.
  • 2Nakano K et al. PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell, 2001, 7:683-694.
  • 3Han Jet al. Expression of Bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and suvival signals. Proc Natl Acad Sci USA, 2001, 98:11318-11323.
  • 4Yu Jet al. PUMA, a potent killer with or without p53. Oncogene, 2009, 27, S71-S83.
  • 5Ming Let al. Spl and p73 activate PUMA following serum starvation. Carcinogenesis, 2008, 29:1878-1884.
  • 6Day CL et al. Structure of the BH3 domains from the p53- inducible BH3-only proteins Noxa and Puma in complex with Mcl-1. J Mol Biol, 2008, 380:958-971.
  • 7Yu Jet al. No PUMA, no death: implications for p53- dependent apoptosis. Cancer Cell. 2003, 4:248-249.
  • 8Jeffers JR et al. Puma is an essential mediator of p53-dependent and p53-independent apoptotic pathways. Cancer Cell, 2003, 4:321-328.
  • 9Yu J et al. PUMA sensitizes lung cancer cells to chemotherapeutic agents and irradiation. Clin Cancer Res, 2006, 12:2928-2936.
  • 10Wang P et al. The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage. Proc Natl Acad Sci USA, 2007, 104:4054-4059.

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生命的化学
2010年 第2期

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