新甲型H1N1流感与中国甲型H1流感HA基因进化比较研究

Comparative Study on Genetic Evolution of Hemagglutinin between Novel Influenza A(H1N1) Virus and Influenza A Virus Subtype H1 from China

目的比较新甲型H1N1流感与中国甲型H1亚型流感病毒HA基因的进化。方法用非度量多维尺度法分析下载自GenBank的中国人和猪甲型H1亚型流感HA序列及WHO北半球流感疫苗推荐株HA序列和新甲型H1N1流感HA序列,构建HA基因进化图谱。结果新甲型H1N1流感病毒HA基因与猪甲型H1亚型流感病毒的亲缘关系较近,而和中国人甲型H1亚型流感病毒及WHO近年推荐的疫苗株亲缘关系很远,并且新甲型H1N1流感病毒HA序列在进化上与中国猪甲型H1亚型流感病毒仍然存在一定距离。结论从基因层面上提示我国人群既往免疫和疫苗对新甲型H1N1流感可能不能提供有效保护,病毒有可能会在人群中流行。同时分析结果提示了尚无证据表明这次始于北美的新甲型H1N1流感来自中国。

Objective To compare the HA genetic evolution of novel influenza A（H1N1） virus and influenza A virus subtype H1 from China.Methods Non-metric multidimensional scaling was used to map the HA genetic evolution of novel influenza A（H1N1） virus,human and swine influenza A virus subtype H1 from China and influenza vaccine.Results A close evolutionary relationship between novel influenza A（H1N1） virus HA gene and swine influenza A virus subtype H1 HA gene was detected.There were distant evolutionary relationships between novel influenza A（H1N1） virus HA gene and human influenza A virus subtype H1 HA gene from China,influenza vaccine.But there was still a little evolutionary distance between novel influenza A（H1N1） virus HA gene and swine influenza A virus subtype H1 HA gene from China.Conclusion It was concluded that at the gene level in China population immunity and vaccine might not provide protection against novel influenza A（H1N1） virus.An influenza pandemic might occur.Meanwhile,there was no evidence that novel influenza A（H1N1） virus might originate in China.