胃癌危险因素的Meta分析

Meta-Analysis of the Risk Factors of Gastric Cancer in China

目的综合评价中国居民胃癌的危险因素,为胃癌的预防控制决策提供参考依据。方法应用Meta分析方法对国内23篇有关胃癌主要危险因素的病例-对照研究结果进行定量综合分析;Review manager4.2进行一致性检验及合并OR值和95%置信区间的计算。结果各因素合并OR值分别为:胃癌家族史OR=5.39(95%CI:2.83～10.25);胃病史OR=5.71(95%:3.64～8.95);饮酒OR=2.92(95%CI:1.57～5.45);吸烟OR=2.36(95%CI:1.60～3.49);高盐饮食OR=2.42(95%CI:1.51～3.86);盐渍食品OR=4.06(95%CI:2.37～6.97);烫食OR=2.46(95%CI:1.30～4.64);饮食不规律OR=2.29(95%CI:1.44～3.65)。结论影响中国胃癌发生的危险因素为家族史、胃病史、饮酒、吸烟、高盐饮食、盐渍食品、烫食和饮食不规律,为胃癌的饮食干预提供了科学依据。

Objective To synthetically evaluate the risk factors of Gastric cancer in China and to provide basis for decision making on Gastric cancer prevention and control.Methods Meta-analysis was used to synthetically and quantitatively evaluate the 23 case-control studies on risk factors of Gastric cancer.Utilized Review Manager 4.2 to do homogeneity checking and calculate pools OR 95% confidence interval.Results The pooled odds ratio values were：family history of gastric cancer,OR=5.39（95%CI：2.83～10.25）;history of gastrosis OR=5.71（95%：3.64～8.95）;alcohol drinking,OR=2.92（95%CI：1.57～5.45）;smoking,OR=2.36（95%CI：1.60～3.49）;intake of high salt diet,OR=2.42（95%CI：1.51～3.86）;intake of salted vegetable,OR=4.06（95%CI：2.37～6.97）;the habit of eating hot food,OR=2.46（95%CI：1.30～4.64）;irregular diet,OR=2.29（95%CI：1.44～3.65）.Conclusion The major factors influencing the incidence of Gastric cancer in China were family history of gastric cancer,history of gastrosis,alcohol drinking,smoking,intake of high salt diet,intake of salted vegetable,the habit of eating hot food,irregular diet,so as to provide scientific proof of dietary intervention.