NF-κB在神经病理性疼痛病理生理过程中发挥的作用

Involvement of NF- κB in the development of neuropathic pain

核转录因子κB（nuclear transcriptrion factorκB，NF—κB）调控着多方面的细胞功能，包括细胞增殖，细胞凋亡，细胞分化，免疫反应等。最近研究表明，NF—κB通过参与神经系统炎症反应、神经细胞凋亡、突触重塑影响神经病理性疼痛。神经病理性疼痛严重影响患者的生活质量，目前仍没有有效的治疗方法，现就近年来NF-κB与神经病理性疼痛的相关研究作一综述。

Nuclear transcription factor κ B （ NF- κ B ） almost plays a role in every aspect of cell regulation： proliferation, apoptosis, differentiation, immune activation.Recent research found that NF- κ B contributes to the development of neuropathic pain via inflammation, apoptosis and synaptic plasticity mechanisms. Neuropathic pain severely affects the quality of a patient＇s life, the management of neuropathic pain is still a major challenge to us.This article provides an overview of recent research on the role of NF- κB in neuropathic pain.