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糖皮质激素受体参与阿片耐受机制的研究进展 被引量:1

Progress in involvement of gincocorticoid receptors in mechanism of opioid tolerance
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摘要 阿片药物耐受是影响临床应用阿片类药物进行疼痛治疗的主要问题。阿片药物耐受机制复杂,有许多调节因素参与其中。近年的研究提示,糖皮质激素受体在阿片耐受机制的各个环节中均发挥调节作用。如能合理利用糖皮质激素受体的这种调节作用,来找到治疗阿片耐受的突破点,将为难治性疼痛的治疗带来福音。 Opioid tolerance is a primary problem which hampers opioids to treat acute and chronic pain. The mechanism of opioid tolerance is complex and is associated with many regulatory factors. Recent studies indicate that glueocorticoid receptors play regulatory role in each link of mechanism of opioid tolerance. It would be beneficial for treatment of intractable pain to find out the methods to treat opioid tolerance by utilizing the regulatory effect of glucocortieoid receptors on opioid tolerance.
出处 《国际麻醉学与复苏杂志》 CAS 2010年第2期166-169,共4页 International Journal of Anesthesiology and Resuscitation
基金 天津医科大学科学基金资助项目(2008kg33) 天津医科大学总医院重点学科基金资助项目
关键词 糖皮质激素受体 阿片耐受 谷氨酸转运体 Glucocortieoid receptors Opioid tolerance Glutamate transporters
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参考文献22

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同被引文献12

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