铜绿假单胞菌265株的临床分布及耐药性分析

Clinical distribution and drug resistance analysis on 265 strains of Pseudomonas aeruginosa

目的:调查铜绿假单胞菌(PAE)临床分布特点及耐药性,为临床合理选用抗菌药物提供参考。方法:回顾性调查分析临床标本中分离的265株铜绿假单胞菌的临床感染特点及其耐药性,药敏试验采用琼脂纸片扩散法。结果:PAE临床分布以ICU及呼吸科最多。临床标本中以呼吸道标本分离率最高,占71.3%,其次为分泌物,占13.6%。PAE对亚胺培南最敏感,耐药率为8.3%;其次是头孢呱酮/舒巴坦,耐药率为12.1%;对其他抗生素均有不同程度的高耐药性、多重耐药性。结论:加强对PAE的耐药性监测,规范抗菌药物的应用,对保持敏感抗菌药物的抗菌活性具有重要意义。

Objective：To investigate the clinical distribution and drug resistane of Pseudomonas aeruginosa so as to provide references for rational use of antibiotics in clinic. Methods：The character of infection and drug resistance of 265 strains of Pseudomonas aeruginosa,which were isolated from clinical wards from January 2007 to June 2009,were analyzed retrospectively.Susceptibility was tested by Kirby-Bauer method.Results：The most location of Pseudomonas aeruginosa were ICU and department of respiratory disease,the samples of respiratory and surgical wound were 13.6% and 71.3% respectively. Pseudomonas aeruginosa had the highest susceptibility to imipenem,the resistant rate to imipenem was the lowest（8.3%）,followed by cefoperazone-sulbactam （12.1%）.It had higher degree drug resistance rates to the other antibacterials,and had higher multidrug-resistant.Conclusion：To reinforce the monitoring on the drug resistance of Pseudomonas aeruginosa and to standardize the application of antibacterials are helpful for the maintaining of antibacterial ac-tivity of sensitive antibacterials.