头孢呋辛钠序贯治疗急性下呼吸道感染2种方案的成本-效果分析

Cost-effectiveness analysis of cefuroxime sodium sequential therapy for acute lower respiratory tract infection

目的:对头孢呋辛钠2种不同给药方案治疗急性下呼吸道细菌性感染的药物经济学评价。方法:将90例急性下呼吸道细菌性感染患者随机分为A、B组,每组各45例。A组采用注射用头孢呋辛钠连续静脉滴注;B组采用注射用头孢呋辛钠及头孢呋辛钠片序贯治疗,两组总疗程均为7d,并进行成本-效果分析。结果:A、B组有效率分别为84.44%、82.22%(P>0.05),细菌清除率分别为95.6%、91.7%(P>0.05),不良反应发生率分别为4.44%、2.22%(P>0.05);A组的治疗费用明显高于B组,A、B组治疗成本分别为823.2、626.1元,成本一效果比分别为1001.22、782.63。结论:头孢呋辛钠序贯疗法治疗下呼吸道细菌性感染较经济。

Objective：To evaluate pharmacoeconomic efficacy of two different dosage regimens of cefuroxime sodium in the treatment of lower respiratory tract bacterial infection.Methods：A total of 90 patients with lower respiratory tract bacterial infection were enrolled：45（group A）were randomly assigned to receive cefuroxime sodium for injection by continuous intravenous drip for 7 d,and other 45 （group B） to receive cefuroxime sodium for injection and cefuroxime sodium capsules by sequential therapy for 7 d. A cost-effectiveness analysis was performed on two groups.Results：For group A and group B,the effective rate was 84.44% ,82.22%（P〉0.05）,the bacterial clearance rate was 95.6%,91.7%（P〉0.05）,and the incidence of ADRs was 4.44%,2.22%（P〉0.05）,respectively、However,the treatment cost in group A （823.2 yuan）was significantly higher than that in group B （626.1 yuan）;the cost-effectiveness ratios of two groups were 1001.22 and 782.63. Conclusion：The sequential therapy of cefuroxime sodium for injection and cefuroxime sodium capsules is economic for lower respiratory tract bacterial infection.