老年期痴呆患者血中氧自由基反应的相关指标

Related Indexes of Oxygen Free Radicals Reaction in the Serum of Senile Dementia Patients

为探讨氧自由基与老年期痴呆发生发展的关系，分别测定了２７例阿尔采默型老年期痴呆（ＳＤＡＴ），２７例多发梗塞性痴呆（ＭＩＤ）患者和３７例同龄的健康老年人血清中超氧化物歧化酶（ＳＯＤ）及其同功酶活性和ＬＰＯ含量．结果显示：ＳＤＡＴ和ＭＩＤ患者的Ｔ－ＳＯＤ、ＣｕＺｎ－ＳＯＤ活性和ＬＰＯ含量均显著高于同龄的对照组，其中ＣｕＺｎ－ＳＯＤ的异常阳性率最高，达５９．３％；Ｔ－ＳＯＤ、ＣｕＺｎ－ＳＯＤ在不同病程的三组间有显著差异．提示ＳＤＡＴ和ＭＩＤ患者体内氧化与抗氧化之间的平衡紊乱，脂质过氧化反应增强，机体抗氧化酶系统的保护功能减弱。

In order to evaluate the role of oxygen free radicals in the pathogenesis of senile dementia,measurements were made on the levels of superoxide dismutase(SOD) with its isoenzyme activity and lipid peroxide(LPO) in 27 alzheimer typed(SDAT) senile dementia cases,27 multi intarctive dementia(MID) and 37 normal cases.The results showed that T SOD,CuZn SOD and LPO content were significantly higher in the patients with SDAT and MID than that in normal controls.The highest abnormal positive rate of CuZn SOD was 59.3%;significant differences of T SOD,CuZn SOD among three different groups were observed.It was suggested that equilibrum between oxidation and antioxidation was interferred with increased lipid peroxide reaction and discreased protection of anti oxidation enzyme system in SDAT and MID patients,which provided a useful basis in discussing the causes and pathogenesis of SDAT and MID.