缺氧诱导因子-1在风湿性疾病发病过程中的作用
摘要
缺氧诱导因子-1(hypoxia-inducible factor-1,HIF-1)是细胞缺氧条件下调控基因表达的主要转录因子之一,Kuwai等于1991年在研究红细胞生成素(erythropoietin,EPO)基因3'末端含有缺氧诱导的增强子序列的过程中发现。HIF.1作为细胞、组织在低氧环境下产生的一系列适应性反应的核心因子,在促进促EPO、葡萄糖载体、血管源性因子生成及细胞增殖等方面发挥着重要的作用。
出处
《实用医学杂志》
CAS
北大核心
2010年第8期1451-1453,共3页
The Journal of Practical Medicine
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