抗环瓜氨酸肽抗体与类风湿因子联合检测在类风湿关节炎早期诊断中的意义

The Significance of Detecting Anti-cyclic Citrullinated Peptide and Heumatoid Factor in the Earlier Diagnosis of Rheumatoid Arthritis

目的比较抗环瓜氨酸肽抗体和类风湿因子在类风湿性关节炎诊断中的价值。方法分别用ELISA法、免疫散射比浊法检测48例RA患者和20例非RA患者及30例正常对照组的抗CCP抗体和RF,分析抗CCP抗体、RF及两者联合检测的敏感度、特异度、阳性预测值和阴性预测值。结果抗CCP抗体的敏感度为66.7%,RF的敏感度为75%,经检验两者无显著性差异。抗CCP抗体的特异度为96%,RF的特异度为84%,两者有显著性差异。两者联合检测可提高敏感度91.7%,特异度下降80%。结论抗CCP抗体对RA的诊断敏感性与RF相当,但特异性较RF明显增高,若两者联合检测有助于提高RA的早期诊断率。

Objective Compare the value of anti-CCP and RA in the diagnosis of RA.Methods Respectively detect the levels of anti-CCP and RA for 48 examples of RA and 20 examples of Non-RA,and 30 examples of normal control with ELISA and Immune nephelometry and analysis the sensitivity,specificity,positive predictive value and negatively predictive value.Results The sensitivity of anti-CCP to be 66.7%,The sensitivity of RF to be 75%,They have no significant difference.The specificity of anti-CCP to be 96%,The specificity of RF to be 84%.There was a significant difference between the two groups.Their combination can increase the sensitivity of 91.7%,specificity declined rate was 80%.Conclusion Anti-CCP in the diagnosis of RA and RF considerable sensitivity all,but specificity was significantly higher than the RF.If the combination of the two tests are helpful to improve the early diagnosis of RA.