1YEO G S,FAROOQI I S,CHALLIS B G,et al.The role of melanocortin signalling in the control of body weight:Evidence from human and murine genetic models[J].Quarterly Journal of Medicine,2000,93(1):7-14.
2KIM K S,LARSEN N,ROTHSCHILD M F.1inkage and physical mapping of the porcine melanocortin-4 receptor(MC4R) gene[J].Journal of Animal Science,2000(78):791-792.
5COSTA J L,BRENNEN M B,HOCHGESEHWENDER U.The human genetics of eating disorders lessons from the leptin/melanoeortin system[J].Child and Adolescent Psychiatric Clinics of North Ameria,2002,1l(2):387-397.
6HOGGARD N, HUNTER L, DUNCAN J S, et al. Regulation of adipose itssue leptin secretion by alpha-melanocyte-stimulating hormone and agouti--related protein: Further evidence of an interaction between leptin and the melanoeortin signailnig system[J]. Molecular Endocrinology, 2004,32 (1) : 145-153.
7HUSZAR D, LYNCH C A, FAIRCHILD HUNTRESS V. Targeted disruption of the melanoeortin 4 receptor results in obesity in mice[J]. Cell, 1997(88) : 131-141.
8GELLER F, REICHWALD K, DEMPFLE A, et al. Melanocortin-4 receptor gene variant I103 is negatively associated with obesity[J]. American Journal of Human Genetics, 2004, 74 (3) :572-581.
9YOUNG E H,WAREHMA N J,FAROOQI S,et al.The V103I polymorphism of the MC4R gene and obesity:Population based studies and meta-analysis of 29563 individuals[J].International Journal of Obesity,2007,3l(9):1437-1441.
10BELL C G,WALLEY A J,FROGUEL P.The genetics of human obesity[J].Nature Review Genetics,2005(6):221-234.
