大叶橐吾化学成分研究

Studies on the Chemical Constituents of Ligularia macrophylla

目的：研究菊科植物大叶橐吾的化学成分。方法：采用硅胶柱色谱进行分离纯化,通过理化性质和波谱数据分析鉴定化合物结构。结果：分离得到8个化合物,分别鉴定为：山奈酚（1）、2,4′-二羟基-5-甲氧基查尔酮（2）、5-羟基-3,4′,7-三甲氧基黄酮醇（3）、isobutyl ester terephthalic acid（4）、4-hydroxybenzaldehyde（5）、mono（2-eth-ylhexyl）terephthalate（6）、羽扇豆醇（7）和β-谷甾醇（8）。结论：化合物1-7为首次从该植物中分离得到。

Objective：To study the chemical constituents of Ligularia macrophylla.Methods：Isolation and purification were carried out on repeated silica gel column chromatography.The structures of the compounds were identified by physico-chemical properties and spectral analyses.Results：Eight compounds were isolated and identified as kaempferol（1）,2,4′-dihydroxy-5-methoxychalcone（2）,5-hydroxy-3,4′,7-trimethoxyflavone（3）,isobutyl ester terephthalic acid（4）,4-hydroxybenzaldehyde（5）,mono（2-ethylhexyl） terephthalate（6）,lupeol（7）,β-sitosterol（8）.Conclusion：Compounds 1～7 are isolated from this plant for the first time.