辛伐他汀与氨氯地平联用治疗舒张性心衰70例疗效观察

Clinical observation of curative effects of simvastatin and amlodipine in vasodilatation heart failure

目的:观察辛伐他汀与氨氯地平联用治疗舒张性心力衰竭(DHF)的有效性和安全性。方法:将70例心功能I～Ⅲ级DHF患者随机分为两组,治疗组给予辛伐他汀与氨氯地平联用;对照组仅给予氨氯地平口服。观察两组患者心功能改善情况,包括多普勒超声心动图测定左心室等容舒张时间(IVRT)、心室舒张早期和晚期充盈速度及其比值(E、A、E/A),并观察血压(BP)、心率(HR)的变化。结果:治疗组在改善心功能包括超声心动图参数:IVRT、E、A、E/A及BP、HR方面明显优于对照组(P<0.05),不良反应少。结论:辛伐他汀与氨氯地平联用治疗DHF的疗效优于单用氨氯地平,安全可靠,值得推广。

Objective：To observe the effect and the safety of simvastatin and amlodipine to treat diastolic heart failure.Methods：70 patients with diastolic heart failure were divided into two groups randomly,the observation group was treated with simvastatin and amlodipine together,and the control group was treated with amlodipine only.after treatment,the improvements of heart function were compared between two groups,including isovolumic relaxation time（IVRT）,the engorge speed at the ventricular diastole earlier period and advanced stage and the ratio of them（E,A,E/A）,the blood pressure（BP） and the heart rate（HR）.Results：The improvement of the parameters of the echocardiogram such as the IVRT,E,A,E/A and BP,HR in the observation group were better than those in the control group（P〈0.05）.The adverse effects were lower compared with the controls.Conclusion：The effect of the combination of simvastatin and amlodipine to treat diastolic heart failure is better than useing amlodipine only.