单核巨噬细胞铁代谢相关蛋白的表达调控

Regulation of Iron-Related Proteins in Mononuclear Phagocyte System

人类机体的铁代谢表现为受限制的对外界铁的吸收和有效的机体内的铁的再循环利用,单核巨噬细胞系统通过吞噬衰老的红细胞,储存和释放铁,在机体铁的循环再利用方面起到了重要的作用。因此,单核巨噬细胞系统对整个机体铁稳态的维持非常重要。近年来,随着转铁蛋白受体1(transferrin receptor1,TfR1)、铁蛋白(ferritin,Fn)、二价金属离子转运蛋白1(divalent metal transporter1,DMT1)、膜铁转运蛋白1(ferroportin1,FPN1),以及铁调素(hepcidin)等在单核巨噬细胞系统中功能和调控机制研究的不断深入,日益加深了人们对单核巨噬细胞系统的铁代谢过程和调控机制的了解。该文综述了铁水平、NO以及炎症等因素对单核巨噬细胞系统TfR1、Fn、DMT1、FPN1、hepcidin等蛋白表达的调控及其机制研究的最新进展。

Iron metabolism in humans is characterized by limited external exchange and by efficient reutilization of iron from internal sources. The mononuclear phagocyte system （MPS） recycles iron from senescent red blood cells and serves as a large storage depot for excess iron. MPS is important to maintain iron homeostasis. Recent studies characterizing the function and regulation of transferrin receptor 1 （TfR1）, ferritin （Fn）, divalent metal transporter 1 （DMT1）, ferroportin1 （FPN1）, and hepcidin are rapidly expanding our knowledge base on the molecular level of MPS iron handling. This review summarizes regulation of TfR1, Fn, DMT1, FPN1, hepcidin by iron level, NO, or inflammation in the MPS.