大黄减轻维持性血液透析患者静脉铁剂诱导的微炎症反应

Effects of rhubarb on microinflammation induced by intravenous iron in maintenance honodialysis patients

目的探讨大黄对维持性血液透析（MHD）患者静脉铁剂诱导的微炎症反应的影响。方法选择在我院血液净化中心行MHD治疗的患者50例，随机分为静脉铁剂治疗组（A组）和静脉铁剂＋大黄治疗组（B组）。B组给予大黄泡水饮服8周。分别于治疗前后检测各组患者血红蛋白（Hb）、红细胞压积（Hct）、血清铁（SI）、铁蛋白（SF）、转铁蛋白饱和度（TSAT），C反应蛋白（CRP），肿瘤坏死因子α（TNF-α）、白细胞介素（IL）-1β、11710等。结果治疗8周后，A组和B组Hb、Hct、SI、SF、TSAT、CRP、TNF-α、IL-1β较治疗前升高；B组CRP、TNF-α、IL-1β均较A组降低（P〈0．01或P〈0．05）；2组IL-10水平差异无统计学意义（P〉0．05）。结论大黄可以减轻静脉铁剂诱导的微炎症反应。

Objective To investigate the effects of rhubarb against microinflammation induced by intravenous iron in maintenance hemodialysis（MHD）patients. Methods Forty-nine MHD patients were randomly allocated to intravenous iron group（group A, n = 24）, and intravenous iron plus rhubarb group （group B,n = 25）. Patients in group B were administered with infused decotion of rhubarb for 8 weeks. The blood levels of hemoglobin （Hb）, hematocrit （Hct）, serum iron （SI）, serulnferritin （SF）, transferring saturation （TAST）,C-reactive protein （CRP）, tumor necrosis factor-α（TNF-α）, interleu- kin （IL）-1β and IL-10 were measured before and after the treatment. Results After treatment, the levels of Hb, Hct,SI,SF,TSAT,CRP, TNF-α,IL-1β in both groups A and B were higher than those before the treatment（P〈0. 05 or P〈0. 01, respectively）. The levels of CRP, TNF-α, IL-1β in group B were lower than those in group A（P〈0.05 or P〈0.01, respectively）. There was no significant difference in the levels of IL-10 amongst two groups. Conclusion Rhubarb can alleviate microinflammation induced by intravenous iron in MHD patients.