5-羟色胺与去甲肾上腺素再摄取抑制药是焦虑障碍的一线治疗药物

5-serotonin and norepinephrine reuptake inhibitor is first line drug for anxiety disorder

焦虑障碍是最常见的精神障碍,具有慢性发作性特点,药物治疗提倡单一用药,足量、足疗程治疗。常用抗焦虑药物中,苯二氮类药物、5-羟色胺1A受体部分激动药、肾上腺素β受体阻滞药、三环类抗抑郁药和非经典抗精神病药的药理作用限制了其长期使用。治疗药物首选5-羟色胺与去甲肾上腺素再摄取抑制药(SNRIs)和5-羟色胺再摄取抑制药(SSRIs)。SNRIs中文拉法辛和度洛西汀独特的去甲肾上腺素、5-羟色胺、多巴胺受体选择性再摄取抑制的药理特点使其成为焦虑障碍治疗的一线药物。

character. Single Commonly used Anxiety disorder is the most common mental disorder with chronic episodic course in drug, sufficient dose and complete treatment course are mandatory as the medication strategy. anti-anxiety drugs, such as benzodiazepine, 5-HT1A receptor partial agonist, β-adrenergic blocker, tricyclic antidepressant and atypical antipsychotics have their shortcomings in long-term treatment due to pharmacological mechanisms. The first choice of medication includes 5-serotonin and norepinephrine reuptake inhibitors （SNRIs） and 5-selective serotonin reuptake inhibitors （SSRIs）. SNRls, such as venlafaxine and duloxetine, with its unique NE, 5-HT, DA receptor reuptake inhibition characteristics, thus become the first line drug treatment for anxiety disorder.