194例药物引起过敏性休克的中文文献分析

Bibliometrical Analysis of Chinese Medical Literature-194 Cases of Drug-Induced Allergic Shock

目的:了解引起过敏性休克药物的种类、频度及其它因素.方法:通过对公开发行的中文医药期刊及文献资料收集得到的药物致过敏性休克194例进行统计和分析。结果:最易引起过敏性休克的药物为抗生素类,占62例,其次为中药制剂和生物制剂,各占20例;出现频率较高的首推低分子右旋糖酐15例及庆大霉素11例;过敏性休克致死共30例.此外,给药途径、多种药物并用、连续长期用药、过敏体质及用药失误等也表明是致过敏性休克的重要因素.

By retrieving the articles about drug-induced allergic shock appearing in the Chinese medical periodicals and in literature. 194 cases of allergic shock reported were analyzed. The antibiotics were identified as main agents responsible for the drug-induced allergic shock (n = 62), followed by preparations of Chinese medicinal herb (n = 20) and biological products (n = 20). The incidences of allergic shock caused by low molecular dextran and gentamycin were highest (n = 15 and n= 11, respectively). 30 deaths related to allergic shock were reported. The route of medication, combined use of more than one drug, long-term uninterrupted use, sensitivity of patients and misuse of the medicines were also accountable for the allergic shock.