2005～2008年我院氨基苷类药应用及不良反应分析

Analysis of Utilization and Adverse Drug Reaction of Aminoglycoside Antibiotics in Our Hospital During 2005-2008

目的:了解我院氨基苷类抗生素应用及不良反应发生情况,以期减少该类药品的不良反应。方法:采用限定日剂量(DDD)法分析2005～2008年我院氨基苷类抗生素的用量及用药金额,并比对同期的药品不良反应报告。结果:氨基苷类抗生素在我院用量呈逐年上升趋势,庆大霉素的主导地位被依替米星取代,异帕米星、奈替米星和阿米卡星用量基本稳定。同期发生的药品不良反应以过敏样反应、皮疹、耳毒性和局部麻木为主。结论:根据病原学慎重选用,加强遗传学检测和血药浓度监测,制定合理的给药方案,对于复杂的革兰阴性菌感染,氨基苷类抗生素仍有良好的应用前景。

Objective：To investigate the use and adverse drug reaction of aminoglycoside antibiotics （AnaAn） in our hospital during 2005-2008, and to valuate its rationality for reducing its adverse drug reaction. Methods：The data about AmAn＇s consumption quantity and consumption sum in our hospital were analyzed with the DDD method. Results：Etimicin dominated the first place among AmAn in our hospital, and replaced Gentamicin. The quantities of Netilmicin, Isepamicin and amikacin were stable. In the same period, the main adverse drug reactions were allergic-like reactions, skin rash, ototoxicity and local numbness. Conclusion： Careful selection according to etiology, genetics testing, stronger monitoring of blood concentration and rational dosage treatment will provide a good prospect in the use of AmAn for the multifaceted gram-nega- tive bacteria infection.