葛根异黄酮类化合物抗动脉粥样硬化药理研究进展

Progress in the pharmaceutical study of Radix puerariae

动脉粥样硬化(Atherosclerosis,AS)是当今导致心脑血管疾病高发的主要因素,越来越多的报道说明中药葛根具有抗动脉粥样硬化的药理作用,其主要有效成分为异黄酮类化合物,以葛根素(puerarin)、大豆苷元(daidzein)和大豆苷(daidzin)研究最多,药理作用也最明显。文中对近年来葛根及其有效成分在动脉粥样硬化方面的研究进行综述。

Atherosclerosis,a progressive disease characterized by the accumulation of lipids and fibrous elements in the large arteries,underlies the vast majority of cardiovascular disease and causes more death and disability worldwide than any other disease.The growing reports show that Radix puerariae（Gegeng）,one of the most famous Chinese medicines,can inhibit the progression of atherosclerotic lesions.Isoflavonoids,such as puerarin,daidzein and daidzin,were considered as the main active components in Radix puerariae.In the present paper,the atheroprotective effects of Radix puerariae and its components have been reviewed and discussed.