水飞蓟宾胶囊治疗非酒精性脂肪肝50例的疗效

Efficacy of silibinin capsules in treating 50 patients with nonalcoholic fat liver

目的:探讨水飞蓟宾胶囊(水林佳)治疗非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)的临床疗效及不良反应。方法:选择NAFLD患者96例,随机分为试验组和对照组,其中,对照组46例,采用静脉点滴甘利欣注射液100 mg+5%葡萄糖注射液250 mL,qd,疗程15 d,复查肝功能,如正常即停药,不正常则继续用药,总观察期为3个月;试验组50例,在静脉点滴甘利欣注射液(qd)同时服用水飞蓟宾胶囊70 mg,tid,疗程15 d,复查肝功能,如正常即停药,不正常则继续用药,观察期为3个月。治疗前后检测转氨酶(TA)、总胆固醇(TC)、三酰甘油(TG)等及超声影像变化,同时观察两组患者用药期间的不良反应。结果:治疗结束时,试验组谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆固醇(TC)、三酰甘油(TG)等均明显下降,肝脏影像学也有明显改善。对照组虽然ALT和AST有所下降,但肝脏影像学无明显改善。治疗组总有效率为90%,对照组有效率为54.3%,有显著性差异(P<0.01),观察期间两组均未出现明显不良反应。结论:水飞蓟宾胶囊具有保肝、降血脂、改善肝纤维化的作用,对NAFLD有良好的效果。

Objective：To evaluate the effect of silibinin capsules in treating nonalcoholic fat liver disease（NAFLD）.Methods：A total of 96 patients with NAFL were randomly divided into two groups：control group and treatment group.In control group,patients（n=46） were injected intravenously（iv） with intravenous infusion of 100 mg ganlinxin in 250 mL 5% glucose,qd,for 15 days.The patients in treatment group（n=50） were treated with ganlincin injection（iv,qd） and 70 mg silibinin capsules,tid,for 15 days.During the 3-month observation period,the liver function was monitored.If it was normal,treatment was ended,otherwise,treatment was continued.Transaminase activity（TA）,total cholesterol（TC）,triglyceride（TG）,ultrasonic image of liver fibrosis were observed before and after treatment.Adverse reactions were also recorded during treatment.Results：In silibinin group,the biochemical indexes were significantly reduced,such as ALT,AST,TC,TG and so on;the liver image was greatly improved.In control group（ganlinxin alone）,ALT and AST were slightly reduced,but the liver image were not improved.The overall effective rate in silibinin group（90%） was significantly higher than that in control group（54.3%,P〈0.01）.No obvious adverse reactions were found in both groups.Conclusion：Silibinin capsules is effective and safe in decreasing blood fat and preventing liver fibrosis,and can be applied to treat NAFLD.