人乳头瘤病毒感染与宫颈癌进展的相关性

Human papillomavirus infection and the tumorgenesis of cervical cancer

人乳头瘤病毒(HPV)是诱发宫颈癌的最重要因素。HPV感染率在人群中虽然比较高,但是,HPV感染绝大多数是自限的。从统计学上看,HPV病毒载量与宫颈癌前病变及宫颈癌进展具有较好的相关性,然而经常可以在高等级病变中发现低载量,在这种情况下,HPV病毒载量预测宫颈癌进展是不利的。最近国际上的成果显示:连续的同一型别高危型HPV感染所形成的持续HPV感染更容易造成宫颈癌进展。因而,可分型的HPV检测方案对于预测持续HPV感染,进而预测肿瘤进展具有更大的意义。

The infection of human papillomavirus （HPV） is an essential factor forthe tumorgenesis of cervical cancer. Most of the HPV infections are self-limited, though the prevalence of HPV infection in the population is high. The viral load of HPV is relative to the development of cervical cancer, however, low viral load was found in a limited number of high-grade pre-cancer samples. Thus, the viral load of HPV might not be an effective index for the development of cervical cancer. Recent infection model for HPV suggested that continued infection with the same genotype of HPV was more close to the development of cervical cancer. From this model, it is obvious that HPV genotyping is more helpful to the predictions for persistent infection of HPv and development of cervical cancer as well.