保妇康栓治疗宫颈持续人乳头瘤病毒感染炎性疾病的临床观察

The efficacy of baofukang suppository for treatment of cervicitis combined with persist HPV infection

目的探讨保妇康栓治疗宫颈炎性疾病合并人乳头瘤病毒(HPV)感染的疗效。方法对2007年1月至2009年8月在中日友好医院妇科门诊宫颈炎合并持续高危型HPV感染≥2年者作为观察组共137例,保妇康栓阴道用药3个疗程(3个月)。对照组131例,不用任何药物观察。用药3个月后,停药1个月返诊行妇科检查及杂交捕获二代(HCⅡ)、液基细胞学(LCT)检测。结果用药3个月后停药1个月,观察组HCⅡ转阴率(38.0%)、HCⅡ检测RLU/CO比值显著改善率(37.2%)均明显高于对照组(22.1%,18.3%)(P<0.01)。宫颈炎指标积分变化(LCT积分+宫颈糜烂积分),观察组痊愈率(61.3%)、显效率(29.9%)均明显高于对照组(0,14.5%)(P<0.01)。结论保妇康栓具有抗菌、消炎及抗HPV感染作用,适于临床应用。

Objective To observe the efficacy of Baofukang suppository for treatment of cervicitis combined with highrisk HPV infection. Methods The objects of observation were outpatients suffered from cervicitis with high-risk HPV infection persisted ≥2 years, between January 2007 to August 2009 at China-Japan Friendship Hospital. 137 cases of these patients were enrolled in test group, used Baofukang suppository vaginally for three courses （3 months）. Additional 131 cases as control group didnt use any drug only given follow-up. 1 month later after 3 months medication, all the patients came back accepted gynecological examination, LCT and HC Ⅱ test. Results 1 month later after 3 months medication, HC Ⅱ negative rate （38.0%）, improved rate of HC Ⅱ RLU / CO ratio （37.2%） in test group were significantly higher than that in control group （22.1%, 18.3% ） （P 〈0.01 ）. As considered eervicitis index （LCT index and cervical erosion index） , the cure rate （61.3%） and markedly effective rate （29.9%） in test group were significantly higher than that in control group （0, 14.5% ） （P 〈0. 01 ）. Conclusion Baofukang suppository has anti-bacterial, anti-inflammatory and anti-HPV infection efficacy.