1,6-二磷酸果糖与肝素治疗难治性心力衰竭疗效比较

Comparison of curative effects on refractory heart failure between 1,6fructose diphosphate and heparin

目的：对１，６二磷酸果糖（ＦＤＰ）与肝素治疗难治性心力衰竭（心衰）的疗效进行比较。方法：５０例难治性心衰患者随机分为２组，分别用ＦＤＰ或肝素静滴，疗程６日。结果：用药后３日，２组的疗效无显著差异（总有效率分别为６０％与６４％），用药４～６日ＦＤＰ组的疗效继续上升（总有效率８８％），而肝素组的疗效无明显进展（总有效率６０％），２组比较差异显著（Ｐ＜０．０１）。治疗后ＦＤＰ组心脏功能各项指标均有明显改善（Ｐ均＜０．０１），肝素组心脏功能各项指标，治疗３日有明显改善（Ｐ均＜０．０１），治疗６日无显著变化（Ｐ均＞０．０５）。ＦＤＰ组治疗后心肌耗氧量显著减少（Ｐ均＜０．０１），而肝素组无明显变化（Ｐ均＞０．０５）。

Objective:To compare the curative effects of 1,6fructose diphosphate (FDP) with heparin on refractory heart failure.Methods:50 cases with refractory heart failure were randomly divided into two groups.The FDP or heparin was infused intravenously and the therapeutic course was 6 days.Results:3 days after using drugs there was no difference in curative effects in comparison between two groups (total effective rate:60% and 64% respectively).46 days after using drugs the curative effects were increasing continously (total effective rate:88%) in FDP group but had not progress (total effective rate:60%) in heparin group.The difference between two groups was significant ( P <0 01).After therapy all the indices of cardiac functions showed significant improvements in FDP group (all P <0 01) meanwhile they did so too 3 days after therapy (all P <0 01) but had no significant changes 6 days after therapy (all P >0 05) in heparin group.After therapy the volumes of myocardial oxygen consumptions were decreased significantly (all P <0 01) in FDP group but they didn′t change (all P >0 05) in heparin group.Conclusions:FDP is better than heparin in treatment for refractory heart failure.