功能化聚六亚甲基盐酸胍的合成与表征

Synthesis and characterization of functionalized poly(hexa-methylene guanidine hydrochloride)

将带有胍基抗菌官能团的聚六亚甲基盐酸胍(PHGC)与甲基丙烯酸环氧丙酯(GMA)反应,制备了含碳碳双键官能团的功能化聚六亚甲基盐酸胍。利用紫外分光光度法测定了反应转化率,并考察了溶剂、反应物配比、反应时间及温度对反应转化率的影响规律。采用FT-IR、Raman、NMR和TG对功能化聚六亚甲基盐酸胍的组成、结构和热稳定性进行了表征。结果表明,在DMSO溶剂中,当GMA与PHGC摩尔比为1:1,在60℃下反应60 h后,反应转化率可达75%,且合成的功能化聚六亚甲基盐酸胍具有良好的热稳定性。功能化聚六亚甲基盐酸胍可用作大分子单体,与其他单体共聚制备具有抗菌性能的聚合物和微球。

Functionalized poly （ hexamethylene guanidine hydrochloride） bearing C =C groups （ F-PHGC ） was synthesized by the reaction between glycidyl methacrylate （GMA） and polyhexamethylene guanidine hydrochloride （PHGC）, which bears antimicrobial guanidine functional groups. The effects of solvent, reactant ratio, reaction time and temperature on the conversion of the reaction were studied via ultraviolet absorption spectrometry. Also, the composition, structure and thermal property of F-PHGC were characterized by infrared spectroscopy （ FT-IR）, Raman spectroscopy, nuclear magnetic resonance （NMR） and TG analysis. The results indicate that when the concentration of PHGC and n（GMA） ： n（PHGC） were 24% （w） and 1 ： 1, the conversion of GMA reached up to 75% after reacting at 60℃ in dimethylsulfoxide （DMSO） for 60 hours. The TG test shows that the resultant F-PHGC has good thermal stability. F-PHGC can be used as macromonomer to copolymerize with other monomers for the preparation of polymers and microspheres with antimicrobial activity.