医院不发酵糖革兰阴性杆菌的耐药性调查

Drug-resistance of Nonfermentative Gram-negative Bacilli

目的探讨医院临床常见不发酵糖革兰阴性杆菌对抗菌药物的耐药性,为临床医师合理用药提供科学依据。方法调查医院铜绿假单胞菌(PAE)、鲍氏不动杆菌(ABA)、嗜麦芽寡养单胞菌(PMA)的分离率及耐药率。结果 388株不发酵糖革兰阴性杆菌中,PAE占44.6%;ABA占33.8%;SMA占11.1%;其他不发酵糖革兰阴性杆菌占10.6%;3种菌株对抗菌药物产生了不同程度的耐药性,且ABA对抗菌药物的耐药率已普遍高于PAE。结论不发酵糖革兰阴性杆菌的耐药性已非常严重,应采取有效措施,预防与控制多药耐药菌医院感染。

OBJECTIVE To investigate drug-resistance of commonly isolated nonfermentative Gram-negative bacilli in the First Renming Hospital of Jingzhou and offer the scientific evidence for reasonable application of antibiotics.METHODS The rates of isolation and drug-resistance of Pseudomonas aeruginosa（PAE）,Acinetobacter baumannii（ABA） and Stenotrophomonas maltophilia（SMA） were investigated.RESULTS Among 388 nonfermenters,PAE accounted for 44.6%,ABA for 33.8%,SMA for 11.1% and the others for 10.6%.Drug-resistance to different degrees had occurred in three nonfermenters.The rates of drug-resistance of ABA were generally higher than those of PAE.CONCLUSIONS The drug-resistance of nonfermentative Gram-negative bacilli is very serious.The effective measures should be adopted to prevent and control the nosocomial infections with multi-resistant strains.